J.TEM：与NAD相关的生物学、代谢、以及在癌症中的作用

近期发表在Trends in Endocrinology & Metabolism上的一篇文章指出， 磷酸核糖转移酶（nicotinamide phosphoribosyltransferase，Nampt）在许多疾病包括2型 糖尿病 和癌症具有重要的生理功能。该文章详细描述了Nampt作为烟酰胺转化为烟酰胺单核苷酸过程的作用，其中最重要的是产生 烟酰胺腺嘌呤二核苷酸磷酸（nicotinamide adenine dinucleotide，NAD），最近由于NAD的生化、代谢、炎症方面的研究深入，Nampt可以调节消耗NAD酶如去乙酰化酶Sirtuin的活性，影响应急与代谢，从而也引起了极大的兴趣，Nampt似乎应该是具有免疫调节功能因子，在炎症中发挥作用。（ 生物谷 Bioon.com）
生物谷推荐原始出处：
Trends in Endocrinology & Metabolism doi:10.1016/j.tem.2008.10.004
Nampt: linking NAD biology, metabolism and cancer
Antje Garten1, , Stefanie Petzold1, Antje K?rner1, Shin-ichiro Imai2, and Wieland Kiess1
1University of Leipzig, Hospital for Children and Adolescents, Research Laboratory, Oststr. 21-25, 04317 Leipzig, Germany2Washington University School of Medicine, Department of Developmental Biology, Campus Box 8103, 660 South Euclid Avenue, St. Louis, MO 63110, USA
Nicotinamide phosphoribosyltransferase (Nampt) converts nicotinamide to nicotinamide mononucleotide (NMN), a key nicotinamide adenine dinucleotide (NAD) intermediate. Previously identified as a cytokine pre-B-cell colony-enhancing factor and controversially claimed as an insulin-mimetic hormone visfatin, Nampt has recently drawn much attention in several fields, including NAD biology, metabolism and inflammation. As a NAD biosynthetic enzyme, Nampt regulates the activity of NAD-consuming enzymes such as sirtuins and influences a variety of metabolic and stress responses. Nampt also plays an important part in regulating insulin secretion in pancreatic β-cells. Nampt seems to have another function as an immunomodulatory cytokine and, therefore, has a role in inflammation. This review summarizes these various functional aspects of Nampt and discusses its potential roles in diseases, including type 2 diabetes and cancer.